This presentation will explore the evolving landscape of clinical skin research, highlighting the pivotal role of advanced imaging and data science while addressing the critical gap in understanding the molecular mechanisms of skin biology. Current methodologies heavily rely on sophisticated imaging techniques that provide detailed visualizations of skin structure and pathology, complemented by novel data analysis approaches that interpret these complex datasets to reveal unprecedented patterns and insights. However, a significant aspect remains underexplored—the molecular mechanisms underpinning skin functions and disorders which explain the morphological features present in imaging. This presentation delves into how integrating molecular biology into the existing imaging framework can enrich our understanding, leading to more targeted and effective interventions. The discussion will cover the latest advancements in imaging technologies and data analytics, showcasing their potential to uncover not just structural and phenotypic data but also guide the discovery of underlying molecular processes. Examples include using high-resolution imaging to track cellular-level changes and applying machine learning models to predict skin disease progression from large-scale datasets. Progress in emerging approaches in skin microsampling, a less invasive method for obtaining skin cells and biomarkers without disrupting skin integrity, will be discussed. This technique is poised to revolutionize skin sample collection for molecular analysis, offering a more detailed molecular landscape of the skin in health and disease. Concluding the presentation, the development of a digital twin for skin—a comprehensive digital model replicating the skin's physical and biochemical properties—is discussed. This groundbreaking tool will serve research, industry, and regulation, offering a step-change improvement in developing, testing, and approving skin care products and pharmaceuticals. By bridging technological and methodological advancements, the digital twin will enhance our fundamental understanding of skin biology and pave the way for personalized and precision dermatology.

Emulsifiers were considered inactive ingredients in the past, and little or no attention was paid to their interaction with the skin barrier. However, in recent years, it has become evident that these ingredients can significantly impact skin physiology. Certain formulations have been found to reduce the thickness of the stratum corneum, which has been attributed to the choice of emulsifier. This means that the benefits provided by active and emollient ingredients in these formulations are mitigated.  Therefore, formulators must select an emulsification system that has no detrimental effect and preferably has a positive effect on the skin barrier. This presentation will discuss the interaction between emulsifiers and the skin, highlighting the importance of selecting the right emulsifier system for effective skincare products.

Most successful business academic partnerships have a shared purpose that benefits society, focuses on the long term and values outputs that go beyond scientific publications and new technology. Research collaborations in dermatology are no exception and a fostering of an entrepreneurial and translational mindset within the team are essential to truly leverage all the expertise and talent available, providing maximum value for both the business and the university. Research translation in dermatology has been the catalyst for much progress in the cosmetics industry and leads not only to new products for consumers, but has also been important in pushing on new claims territories and providing education to members of the public. Retinol, peptides and other products in skincare can directly trace their origins back to research programs. In addition, research has helped us to better understand the changes in skin over time, helping us to make more relevant and meaningful claims to our consumers. This is not only in ageing-related changes to skin appearance, but also in UV protection. Further to this, it is important for us to use and disseminate dermatology research to increase the knowledge the public have about their skin and how different factors can impact its health, helping them to make the best choices for their skin. Dermatological research has been and continues to be the bed rock of the cosmetic industry and if we manage to ask the right questions and translate with excellence the answers, then we can make an important contribution, helping people achieve healthy skin for them, for life.